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Author's Guide

Information for Authors
GENERAL INFORMATION
The Journal of Genetic Medicine (J Genet Med; JGM) is an international, peer-reviewed open access journal regarding medical genetics and is published twice a year in English. The Journal is published by the Korean Society of Medical Genetics. JGM focuses on review articles, original articles, and case reports in the fields of clinical, experimental, and medical genetics. Manuscripts from any researcher in the world are welcome for submission if they are within the aim and scope of this journal.

RESEARCH AND PUBLICATION ETHICS
For the policies on research and publication ethics that are not stated in these instructions, the Good Publication Practice Guidelines for Medical Journals [1, 2] or the Guidelines on Good Publication Practice [3] can be applied. The Editorin- Chief reserves the right to reject manuscripts that do not comply withtheabove-mentionedrequirements.Theauthor will be held responsible for false statements or failure to fulfill the above-mentioned requirements.

□ Authorship
All authors must have participated in the research and/ or article preparation. Individuals listed as authors must: 1) agree to be listed; 2) have contributed to the research reported; and 3) approve the submitted version of the manuscript. Each author should sign the Authorship Responsibility and Copyright Transfer Agreement Form attesting that he/she fulfils the authorship criteria. The statement that all authors have approved the final article should be true and be included in the disclosure.

□ Conflict of interest statement
A conflict of interest may exist when an author (the author’s institution or employer) has financial or per-sonal relationships or affiliations that could bias the author’s decisions regarding the manuscript. Authors are expected to provide detailed information about all relevant financial interests and relationships or financial conflicts, particularly those present at the time the research was conducted and through publication, as well as other financial interests (such as patent applications in preparation), that represent potential future financial gain. All disclosures of any potential conflicts of interest, including specific financial interests or relationships and affiliations (other than those affiliations listed on the title page of the manuscript) relevant to the subject of the manuscript will be disclosed by the corresponding author on behalf of each co-author, if any, as part of the submission process. Likewise, authors without conflicts of interest will be requested to state as such as part of the submission process. If authors are uncertain about what constitutes relevant financial interests or relationships, they should contact the editorial office.

□ Statement of informed consent
Copies of written informed consent and institutional review board (IRB) approval for clinical research should be kept. If necessary, the editor or reviewers may request copies of these documents to resolve questions about IRB approval and study conduct.

□ Statement of human and animal rights
Clinical research should be performed in accordance with the Ethical Principles for Medical Research Involving Human Subjects, outlined in the Declaration of Helsinki. Clinical studies that do not comply with these requirements will not be considered for publication. For human subjects, personal information such as patient names, individual registration numbers, date of birth, or other private matters should not be disclosed. For animal subjects, research should be conducted according to the National or Institutional Guidelines for the Care and Use of Laboratory Animals, and these facts must be declared in the manuscript. Copies of the protocol approved by the IRB or Animal Ethical Committee (AEC) should be available for review if necessary. Please consult the ’Editorial and Publishing Policies’ for more information.

□ Originality and duplicate publications
All submitted manuscripts should be original and should not be in consideration by other scientific journals for publication. No part of the accepted manuscript should be duplicated in any other scientific journal without the permission of the editorial board. If a duplicate publication related to a paper in this journal is discovered, the authors will be identified in the journal, their institutions will be informed, and penalties will be assessed to the authors.

PEER REVIEW PROCESS
All manuscripts will be reviewed by two or more experts in the corresponding field. Upon completion of the review, authors will receive notification of the editor’s decision by e-mail, with comments offered by the reviewers. The review process will be completed through the second review system. The editorial board will make a final decision on the approval for publication of the submitted manuscripts and can request further revisions if necessary. Statistical editing may be necessary if the data require professional statistical assistance. Manuscript acceptance is based on many factors, including the importance, originality, and priority of the research. A referee’s decision is marked as, ‘Accept,’ ‘Minor Revision,’ ‘Major Revision,’ or ‘Reject.’ If there is a marked discrepancy in the decisions among referees or in opinions between the author and referee(s), the editor may send the manuscript to another referee for additional comments and recommend another decision. Reviewed manuscripts are returned to the corresponding author with comments and recommended revisions with the names and decisions of the referees removed. A final decision on acceptance or rejection for publication is forwarded to the corresponding author from the editorial office. The review and publication processes that are not described in the Instructions to Authors will be incorporated into the Editorial Policy Statements approved by the Council of Science Editors Board of Directors [3].

MANUSCRIPT MANAGEMENT SYSTEM
Authors should submit manuscripts via the electronic manuscript management system for JGM, http://www.e-kjgm. org. Any researcher anywhere in the world can submit a manuscript with the appropriate scope. After creating an account, the author can proceed with the submission process. A cover letter, electronic copy of the manuscript, figures, and tables should be included in the submission file package.The revised manuscript should be submitted through the same web-based system under the same identification number. Please consult ’Author Instructions’ for additional information during manuscript preparation.

REFERENCE STYLE AND FORMAT (NLM’S CITING MEDICINE)
The Uniform Requirements style is based largely on an ANSI standard style adapted by the National Library of Medicine (NLM) for its databases. Authors should consult the National Library of Medicine’s Citing Medicine (www.nlm.nih.gov/ citingmedicine/) for information on NLM’s recommended citation formats for a variety of reference types. References should be numbered consecutively in the order in which they are first mentioned in the text. Identify references in the text, tables, and legends using Arabic numerals in square brackets. References cited only in tables or figure legends should be numbered in accordance with the sequence established by the first identification of the particular table or figure in the text. The titles of journals should be abbreviated according to the style used in Index Medicus. Consult the list of Journals Indexed for MEDLINE and that of KoreaMed, published annually as separate publications by the National Library of Medicine.These lists can also be obtained through the library’s web site. Journals vary as to whether they require authors to cite electronic references within parentheses in the text or in numbered references following the text. Authors should consult with the journal to which they plan to submit their work.

KEYWORDS ACCORDINGTO MeSH
These keywords will assist in cross-indexing the article. Terms from the Medical Subject Headings (MeSH) list of Index Medicus should be used; if suitable MeSH terms are not yet available for recently introduced terms, currently accepted terms may be used.

UNITS OF MEASUREMENT
Authors must consult the Author Information and should report laboratory information in the International System of Units (SI). Editors may request that the authors add alternative or non-SI units before publication since SI units are not universal. Drug concentrations may be reported in either SI or mass units, but the alternative should be provided in parentheses where appropriate.

ABBREVIATIONS AND SYMBOLS
Use only standard abbreviations. The use of non-standard abbreviations can be extremely confusing to readers. Avoid abbreviations in the title. The full term for an abbreviation should precede its first use in the text unless it is a standard unit of measurement.

PUBLICATION CHARGE
The publication fee is free regardless of the membership. However, the reprint cost is 50,000 KRW up to 30 copies, and 50,000 KRW per additional 30 copies.

REFERENCES
1. Korean Association of Medical Journal Editors. Good Publication Practice Guidelines for Medical Journals. Seoul (Korea): Korean Association of Medical Journal Editors. 2008. [ http://kamje.or.kr/publishing_ethics.html] 2. International Committee of Medical Journal Editors. Uniform Requirements for Manuscripts Submitted to Biomedical Journals: Writing and Editing for Biomedical Publications. 2007. [http://www.icmje.org/2007_urm.pdf 2009-06-04] 3. Committee on Publication Ethics: Guidelines on Good Publication Practice. London (United Kingdom): Committee on Publication Ethics. 1999. [http://publicationethics.org/ resources/guidelines]
Instructions to Authors
MANUSCRIPT SUBMISSION SYSTEM
Authors should submit manuscripts via the electronic manuscript management system for JGM, http://www.e-kjgm. org. Please log in as a member of the system and follow the directions. Any researcher anywhere in the world can submit a manuscript as long as the scope is appropriate. After creating an account, an author can proceed with the submission process. A cover letter and an electronic copy of the manuscript, figures, and tables should be included in the submission file package. The revised manuscript should be submitted through the same web system under the same identification numbers.

Queries concerning manuscript submission should be directed to:

Editor-in-Chief: Dong Hyun Cha MD, PhD.
Tel: +82-2-3453-6438, Fax: +82-2-3468-3464
E-mail: bestchadh@naver.com
Mail address: Genetics Laboratory, Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University School of Medicine, Vision Bldg. 4th floor, 8, Nonhyeon-ro 105-gil, Gangnam-gu, Seoul 135-907, Korea

MANUSCRIPT PREPARATION AND FORMAT
Manuscripts must be written in clear and proper English. Manuscripts should be submitted in Microsoft Word (.doc or .docx) format. Manuscripts should be typed on A4 sized paper and should be double-spaced, using a font size of 12 with margins of 25 mm on each side and 30 mm at the top and bottom. The JGM recommends for the original articles as follows. The manuscript should be arranged in the following sequence: (a) Title, author(s), complete address(es) of institution(s), and running title; (b) Abstract and key words; (c) Introduction; (d) Materials and methods; (e) Results; (f) Discussion; (g) Acknowledgements (if necessary); (h) conflict of interest statement; (i) References; (j) tables; (k) figure legends; and (l) figures. Each new section should begin with the section heading on a new page. All pages should be numbered consecutively starting from the title page. Page numbers should be placed at the middle of the bottom of the page.

1. ORIGINAL ARTICLES
The structure of every original article should consist of the title page, abstract and key words, Introduction, Materials and Methods, Results, Discussion, Acknowledgements (if necessary), Conflict of interest, References, Tables, Figure legends, and Figures. Each section should be written according to the following rules.

□ Title page
The title should be as short and informative as possible and should not contain nonstandard abbreviations, subtitles, or colons nor should it exceed 20 words. Only the first letter of the first word of the title should be capitalized.The title page should give the full names of all authors and their institutional affiliation(s). If several authors and institutions are listed, the department and institutional affiliations of each author should be indicated using superscript numbers in sequence. In a separate paragraph, an address for correspondence, including the author name, academic degree, address (institutional affiliation, city, zip code and country), telephone and fax numbers, and email address (if available), should be provided.The running title is to be printed at the top of each page of a published paper and cannot exceed ten words.The word count should include text only, excluding the title, abstract, acknowledgments, conflict of interest statement, references, tables, and figure legends and should be provided at the end of the title page.

□ Abstract and Key Words
The abstract should be concise, less than 250 words, and should describe succinctly, each in a separate paragraph, the Purpose, Materials and Methods, Results, and Conclusion of the study. Abbreviations, if needed, should be kept to an absolute minimum and should include proper identification. A list of a maximum of ten keywords should should be concise but sufficient to allow other researchers to reproduce the results. Only truly new procedures should be described in detail; previously published procedures should be cited using references. When reporting clinical studies or experiments with human subjects, the authors should indicate whether they received approval from the IRB. When reporting clinical studies or experiments with animal subjects, the authors should indicate whether the handling of the animals was supervised by the Institutional Board for the Care and Use of Laboratory Animals. Please consult the ’Editorial and Publishing Policies’ for additional information. Materials and devices should be accompanied by the model name, company name, city, and coun try of the manufacturer. Subsection titles can be used. Precisely describe the methods of statistical analysis and programs with sufficient detail to enable a reader with access to the original data to verify the reported results.

□ Results
Results should be presented in a logical sequence in the text, tables, and illustrations, providing the main or most important findings first. Do not repeat all of the data in the tables or illustrations; instead emphasize or summarize only the most important observations. Results can be separated using subsection titles. Labels of tables and figures should be provided asTable X and Fig. X.

□ Discussion
This section should emphasize the new and important aspects of the study. Do not repeat the results in detail or any other information that is given in the Introduction or Results section. Speculation is permitted, but it must be directly supported by the newly presented data and be well founded. Limitations and further requirements may be described. Conclusions must be stated briefly in the final paragraph of the Discussion section.

□ Acknowledgements
Persons or institutes who contributed to the papers but not sufficiently to be coauthors may be introduced in this section. Financial support, including foundations, institutions, pharmaceutical and device manufacturers, private companies, intramural departmental sources, or any other support may be described.

□ Conflict of interest statement
The corresponding author of an article is asked to inform the editor of the authors’ potential conflicts of interest, which could possibly influence their interpretation of the presented data. A potential conflict of interest should be disclosed in the manuscript even when the authors are confident that their judgments have not been influenced. Such conflicts may be financial support or private connections to pharmaceutical companies, political pressure from interest groups, or academic problems (e.g., employment/affiliation, grants or funding, consultancies, stockownership or options, royalties, or patents filed, received, or pending).

□ References
References should be obviously related to the submitted document and should not exceed 40 in number. References should be numbered consecutively in the order in which they are first mentioned in the text. Each reference should be cited, e.g., [2-4], at the end of the related phrases in the text. The abbreviated journal title should be used according to the List of Journals Indexed for MEDLINE [5] and the List of KoreaMed Journals [6]. If there are six or fewer authors in a reference, then all author names should be listed. If there are more than six authors, list the initial six authors, and then substitute the rest of the authors with ’et al.’ Provide the beginning and final page numbers of the cited reference. Abstracts from conferences are not allowed to be included in the references. Unless otherwise stated, the references should follow the NLM Style Guide forAuthors, Editors, and Publishers [7].

Reference styles
• Article within a journal
Goswami HK, Shrivastava N, Gopal SK, Sharna S, Chandorkar M, Lee IH, et al. Unusual chromosomal features in a child with gradual disappearance of right ulna (mono ostolic osteolysis). J Genet Med 1997;1:11-6. Yoo HW, Kim GH. Molecular characterization and prenatal molecular evaluation of three fetuses in four un-related Korean families with Lesch-Nyhan syndrome. J Genet Med 1998;2:17- 22.

• Article within a journal supplement
Orengo CA, Bray JE, Hubbard T, LoConte L, Sillitoe I. Analysis and assessment of ab initio three-dimensional prediction, secondary structure, and contacts prediction. Proteins 1999; 43(Suppl 3):149-70.

• Article in press
Kharitonov SA, Barnes PJ. Clinical aspects of exhaled nitric oxide. Eur Respir J 2011, in press.

• Complete book
Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine. 3rd ed. New York: Oxford University Press, 1999.

• Book chapter
De Girolami U, Frosch MP, Anthony DC. The central nervoussystem. In: CotranRS,KumarV,Robbins SL, eds. Robbins Pathologic Basis of Disease. 5th ed. Philadelphia: WB Saunders, 1994;1295-356.

• Book authored by an institution
Advisory Committee on Genetic Modification. Annual Report. London, 1999.

• Link/URL
The Mouse Tumor Biology Database. [http://tumor.informatics. jax.org/mtbwi/index.do]

• Link/URL with author(s)
Neylon C. Open Research Computation: an ordinary journal with extraordinary aims. [http://blogs.open accesscentral. com/blogs/bmcblog/entry/open_research_ computation_an_ ordinary]

□ Tables
Tables should be simple and should not duplicate information from figures. Each table should have a concise heading, should be on its own page, and must have an explanatory title and sufficient explanatory material. The first letter of the first word should be capitalized. Tables are numbered with Arabic numerals in order of citation in the text. All tables should be referred to in the text, with their approximate positions indicated in the margin of the manuscript.The table function in MS Word should be used to create tables so that cells can be easily re-sized by the typesetters to fit the page.TheTab key should never be used to generate tables nor should the space bar be used to adjust spaces. It is recommended that a table not exceed one page. Table footnotes should explain all abbreviations, and lower case letter superscripts, a, b, c..., should be used for special remarks.

□ Figure legends
Figure legends should be included in the main manuscript text file rather than being a part of the figure file. Do not use separate pages for each legend. A legend should briefly describe the data shown, explain any abbreviations or reference points in the photographs, and identify all units, mathematical expressions, abscissas, ordinates, and symbols. Capitalize the first letter of the first word, and place a period at the end of the phrase. For each figure, the following information should be provided: figure number (in sequence, using Arabic numerals -i.e., Fig. 1, 2, 3); short figure title (maximum 15 words); detailed legend, up to 300 words.

□ Figures
Figures should be provided as separate files, not embedded in the main manuscript file. Each figure should be submitted as a single file. Figures should be submitted in TIFF, JPG (JPEG), or PDF file format. All figures should be termed ’Fig.’ and labeled with Arabic numerals. Lettering and symbols to appear in each drawing should be at the same points in each image.The conventions for abbreviations used in the journal should be noted so that the usage in illustrations and text are consistent. All figures should be cited in the text (e.g., Fig. 1, Fig. 1A, Figs. 1BD, Figs. 1 and 2). Individual figure files should not exceed 10 MB. Multiple figures under one figure number should be marked on the photographs using capital letters in the lower left corner. Symbols, arrows, or letters used in photographs should contrast well with the background. Photographs and illustrations should be professionally prepared. Color and black and white photographs must be produced at 300 dpi or higher, and line drawings must be produced with higher resolution (600 dpi or higher). The preferred size of a photograph is 8×8 cm, but a one-page width (16.5 cm in width ×8 cm in length) is also acceptable. Photographs must be of sufficient contrast to withstand the inevitable loss of contrast and detail that occurs during the printing process. When the figures are reduced to the size of a single-column or of a single-page width, the smallest parts of the figure must be legible. Electronic and light microscopic photographs must be original or scanned copies of the original. Scales should be presented as a bar in the picture or as a magnification indication in the legend. All figures may be reduced, enlarged or trimmed by the editor for publication. Authors should review the images of such files on a computer screen to be sure they meet their own quality standards. The complete expense of reproducing color photographs and illustrations will be charged to the author. The author is responsible for submitting figure files that are of sufficient quality to permit accurate reproduction and for approving the final color galley proof.

2. REVIEW ARTICLES
Review articles are usually solicited by the Editor-in-Chief; however, unsolicited reviews will also be considered. Authors should contact the Editor-in-Chief in advance to determine the appropriateness of their review article for publication. Unsolicited reviews will undergo peer review. Previously published material should be incorporated into an integrated presentation of our current understanding of a topic.Topics of scientific consensus as well as topics that remain controversial may be discussed in the reviews. These types of articles should have the following structure: Title, Abstract and Key Words, Introduction,Text, Conclusion, Acknowledgements (if necessary), Conflict of interest statement, References (no more than 100),Tables, Figure legends and Figures. Abstracts should summarize the important points in the review article in one paragraph (not to exceed 250 words) with no typical structure. Except for the Abstract,Text, and Conclusion, all sections must follow the same rules for original articles. Review articles are accepted after editorial evaluation.

3. CASE REPORTS
Unique cases that make an important teaching point or scientific observation may be suitable as case reports. A case report should consist of a Title, Abstract and Key Words, Introduction, Case description, Discussion,Acknowledgments (if necessary), References (no more than 20), Tables, Figure legends, and Figures. Abstracts should summarize in one paragraph (not to exceed 250 words) the important points in the case report, with no typical structure. Except for the abstract and case description, all sections must follow the same rules for original articles.

4. REVISIONS
Revisions are usually requested to address the criticisms and comments made by the referees. The corresponding author must provide a point-by-point response to clearly indicate the alterations made in response to the referee’s comments. If references, tables, or figures are moved, added, or deleted during the revision process, they should be renumbered so that all tables, references and figures are cited in the text in numeric order. The author’s revisions should be completed within 14 days after the request. If the author has not uploaded the revised files by the due date, the paper shall be considered withdrawn.To extend the revision period, the authors should contact the editor.

GENERAL TEXT STYLE

□ Names of drugs, devices, and other products
Generic names should be used. When a proprietary brand is used in research, include the brand name and the name of the manufacturer in parentheses after the first mention of the generic name in the Materials and Methods section.

□ Gene names, symbols, and accession numbers
Authors describing genes, chromosomes, or related structures in a manuscript should include the names and official symbols provided by the US National Center for Biotechnology Information (NCBI), International System for Human Cytogenetic Nomenclature (ISCN), or the HUGO Gene Nomenclature Committee (http://www.genenames. org).

□ Statistical expressions
Mean and standard deviation should be described as mean ±SD and mean andstandard error as mean±SE. P -values shouldbedescribedas P<0.05 or P=0.003.

□ Units of measurement
Scientific units should be used based on the International System of Units (SI). The unit for volume is ‘L’ instead of ‘l’ to avoid confusion; the unit for blood pressure is mmHg; temperature is expressed in Celsius, and the units for concentration are mol or some fraction thereof.

□ Numbers
In the text, numbers should be Arabic numerals, except when beginning a sentence. Numbers greater than 999 should have commas, e.g., 13,970.The 24-hour system is used to indicate time, e.g., 18 hr, 30 min.

□ Abbreviations and symbols
Standard abbreviations may be used without definition. Any nonstandard abbreviations should be spelled out on first use, followed by the abbreviated form in parentheses. Thereafter, the abbreviated form may be used throughout the manuscript. Undefined abbreviations are not allowed. To make papers more readable and informative, the JGM requests that authors mark the following in italics for typesetting. - Biological names of organisms: Saccharomyces cerevisiae, E. coli - Restriction enzymes and other appropriate enzymes: Eco RI,Taq polymerase - Name of genes: src, c-H-ras, myc - Latin words: in vivo, in vitro, in situ - Appropriate chemical structure words: trans-retinol, cis - acting, N-carbamoylaspartate Abbreviations should be avoided as much as possible. Do not use abbreviations in the title and limit their use in the text. When they are used, full expression of the abbreviations following the abbreviated word in parentheses should be given at the first use. An abbreviation can be used if it is listed as a MeSH subject heading [6] or if it is approved by the International System of Units [8].

GALLEY PROOF
JGM provides the corresponding author with galley proofs of their corrections. Corresponding authors will receive electronic page proofs to verify the copyedited and typeset article before publication. Files of the typeset pages and supporting documents (e.g., reprint order form) will be sent to the corresponding author by e-mail. Complete instructions will be provided with the e-mail for downloading and printing the files and for faxing the corrected page proofs to the publisher. Corrections should be kept to a minimum. The editor retains the perogative to question minor stylistic alterations and major alterations that might affect the scientific content of the paper. Authors may be charged for alterations to the proofs beyond those required to correct errors or to answer queries. Any fault found after publication is the responsibility of the authors. We urge our contributors to proofread their accepted manuscripts very carefully.The corresponding author may be contacted by the editorial office, depending on the nature of the correction in the proof. If the proof is not returned or faxed to the editorial office within 48 hours, it may be necessary to reschedule the paper for a subsequent issue.

COPYRIGHT
Copyrights of all published materials are owned by the Korean Society of Medical Genetics. All authors of accepted manuscripts must sign a copy of the ‘Copyright Assignment & Warranties Form,’ which is available on the official website of JGM (http://www.e-kjgm.org) and should be submitted at the time of manuscript submission or a copy can be faxed to +82 3468-3464.

SUBSCRIPTION INFORMATION
JGM is not for sale but is distributed to members of the Korean Society of Medical Genetics. However, JGM is an an Open Access Journal, of which full text articles are freely available at the official website (http://www.e-kjgm.org or http://www. ksmg.or.kr).

REFERENCES
1. National Library of Medicine (US): MeSH. Bethesda (MD): National Library of Medicine (US). 1954. [http://www.ncbi. nlm.nih.gov/sites/entrez?db=mesh]
2. Korean Association of Medical Journal Editors. Good Publication Practice Guidelines for Medical Journals. Seoul (Korea): Korean Association of Medical Journal Editors. 2008. [ http://kamje.or.kr/publishing_ethics.html]
3. International Committee of Medical Journal Editors. Uniform Requirements for Manuscripts Submitted to Biomedical Journals: Writing and Editing for Biomedical Publications. 2007. [http://www.icmje.org/recommendations/ archives/2007_urm.pdf]
4. Committee on Publication Ethics: Guidelines on Good Publication Practice. London (United Kingdom): Committee on Publication Ethics. 1999. [http://fampra.oxfordjournals. org/content/17/3/218.full.pdf+html]
5. National Library of Medicine (US): Journals. Bethesda (MD): National Library of Medicine (US). 2009. [http://www.ncbi. nlm.nih.gov/sites/entrez?db=journals]
6. Korean Association of Medical Journal Editors: KoreaMed: List of Journals. Seoul (Korea): Korean Association of Medical Journal Editors. 1997. [http://www.koreamed.org/ JournalBrowser.php]v 7. Patrias, K. Citing medicine: the NLM style guide for authors, editors, and publishers. 2nd ed. Wendling, DL, technical editor. Bethesda (MD): National Library of Medicine (US). 2007. [http://www.nlm.nih.gov/citingmedicine] 8. International Bureau of Weights and Measures: The International System of Units. Cedex (France). 1799. [http:// www.bipm.org/en/si/]
Conflict of Interest Disclosure
Public trust in the peer review process and the credibility of a published article depend in part on how well conflicts of interest are handled during writing, peer review, and editorial decision making. A conflict of interest exists when an author (or the author’s institution), reviewer, or editor has financial or personal relationships that inappropriately influence (bias) his or her actions (such relationships are also known as dual commitments, competing interests, or competing loyalties). These relationships vary from those with negligible potential to those with great potential to influence judgment, and not all relationships represent a true conflict of interest. The potential for conflict of interest can exist whether or not an individual believes that the relationship affects his or her scientific judgment. Financial relationships (such as employment, consultancies, stock ownership, honoraria, paid expert testimony) are the most easily identifiable conflicts of interest and the most likely to undermine the credibility of the journal, the authors, and of science itself. However, conflicts can occur for other reasons, such as personal relationships, academic competition, and intellectual passion. All participants in the peer review and publication processes must disclose all relationships that could be viewed as a potential conflict of interest. Disclosure of these relationships is also important in connection with editorials and review articles because it can be more difficult to detect bias in these types of publications than in reports of original research. Editors may use information disclosed in conflict of interest and financial interest statements as a basis for editorial decisions. Editors should publish this information if they believe it is important in judging the manuscript.

1. Potential Conflicts of Interest Related to Individual Authors
Authors should identify individuals who provided writing or other assistance and should disclose the funding source for this assistance. Investigators must disclose potential conflicts to study participants and should state in the manuscript whether they have done so. Editors also need to decide when to publish information disclosed by authors about potential conflicts. If doubt exists, it is best to err on the side of publication.

2. Potential Conflicts of Interest Related to Editors, Staff, or Reviewers
Editors should avoid selecting external peer reviewers with obvious potential conflicts of interest, for example, those who work in the same department or institution as any of the authors. Authors often provide editors with the names of persons they feel should not be asked to review a manuscript because of potential conflicts of interest, usually of a professional nature. When possible, authors should be asked to explain or justify their concerns; that information is important to editors in deciding whether to honor such requests. Reviewers must disclose to editors any conflicts of interest that could bias their opinions of the manuscript, and they should disqualify themselves from reviewing specific manuscripts if they believe it to be appropriate. As in the case of authors, silence on the part of reviewers concerning potential conflicts may mean either that conflicts exist that they have failed to disclose, or that conflicts do not exist. Reviewers must therefore also be asked to explicitly state whether conflicts exist. Reviewers must not use knowledge of the work, before its publication, to further their own interests. Editors who make final decisions about manuscripts must have no personal, professional, or financial involvement in any of the issues they might judge. Other members of the editorial staff, if they participate in editorial decisions, must provide editors with a current description of their financial interests (as they might relate to editorial judgments) and disqualify themselves from any decisions in which they have a conflict of interest. Editorial staff must not use the information gained through manuscript review for personal gain. Editors should publish regular disclosure statements about potential conflicts of interests related to the commitments of journal staff.
Author Check List
Please check off each of the following steps as it is completed:

□ Double-spaced with 12-point font

□ A cover letter stating the scientific significance, an assurance that the material has not been published previously and will not
be submitted for publication elsewhere, and conflicts of interest of all listed authors, if any, are included.

□ Arranged in the following sequence: title page, abstract and keywords, introduction, materials and methods, results,
discussion, acknowledgments, conflict of interest statement, references, tables, figure legends, and figures. All pages should be
numbered consecutively starting from the title page.

□ Title page with article title, author’s full name(s) and affiliation, address for correspondence (including telephone and fax
numbers and e-mail address), and running title (less than ten words).

□ Title page includes a word count for text only, excluding the title, abstract, acknowledgments, conflict of interest statement,
references, tables, and figure legends.

□ Abstract in structured format with the following headings: purpose, materials and methods, results, and conclusion (less than
250 words), in addition to MeSH key words.

□ Serial line numbers are provided from the beginning of the main text.

□ References are listed in proper format.All references listed in the references section are cited in the text and vice versa.

□ A title for each table and figure (a brief phrase no longer than 10 to 15 words) and an explanatory legend are included as
needed.

□ All tables and figure numbers are included in the main body text.

□ Figure images are complete (resolution, size, etc.) as provided in the JGM guidelines.

□ Each author has read the manuscript and agrees with the submission.